P02A201 Caspase-3(Pro+p17) mAb
发布时间：2020-01-15 13:47 来源：市场部
Caspase-3(Pro+p17) mAb
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货号 |
P02A201 |
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规格 |
20ul/50ul/100ul |
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种属反应性 |
Human |
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应用 |
WB, IF/ICC,IP, FC |
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宿主 |
Rabbit |
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说明书下载 |
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Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helixloop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Catalytic activity Strict requirement for an Asp residue at positions P1 and P4.
