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P02A201 Caspase-3(Pro+p17) mAb
发布时间:2020-01-15 13:47 来源:市场部
Caspase-3(Pro+p17) mAb

货号 P02A201
规格 20ul/50ul/100ul
种属反应性 Human
应用 WB, IF/ICC,IP, FC
宿主 Rabbit
说明书下载
P02A201说明书

Background:
       Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helixloop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. Catalytic activity Strict requirement for an Asp residue at positions P1 and P4.